Ontology highlight
ABSTRACT:
SUBMITTER: Waterland RA
PROVIDER: S-EPMC165709 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Waterland Robert A RA Jirtle Randy L RL
Molecular and cellular biology 20030801 15
Early nutrition affects adult metabolism in humans and other mammals, potentially via persistent alterations in DNA methylation. With viable yellow agouti (A(vy)) mice, which harbor a transposable element in the agouti gene, we tested the hypothesis that the metastable methylation status of specific transposable element insertion sites renders them epigenetically labile to early methyl donor nutrition. Our results show that dietary methyl supplementation of a/a dams with extra folic acid, vitami ...[more]