Ontology highlight
ABSTRACT:
SUBMITTER: Moore LB
PROVIDER: S-EPMC16574 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
Moore L B LB Goodwin B B Jones S A SA Wisely G B GB Serabjit-Singh C J CJ Willson T M TM Collins J L JL Kliewer S A SA
Proceedings of the National Academy of Sciences of the United States of America 20000601 13
St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies demonstrate that hypericum extracts increase the metabolism of various drugs, including combined oral contraceptives, cyclosporin, and indinavir. In this report, we show that hyperforin, a constituent of St. John's wort with antidepressant activity, is a potent ligand (K(i) = 27 nM) for the pregnane X receptor, an orphan nuclear receptor that regulates expression of the ...[more]