Ontology highlight
ABSTRACT:
SUBMITTER: Nicolussi S
PROVIDER: S-EPMC7056460 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nicolussi Simon S Drewe Jürgen J Butterweck Veronika V Meyer Zu Schwabedissen Henriette E HE
British journal of pharmacology 20200117 6
The first clinically relevant reports of preparations of St. John's wort (SJW), a herbal medicine with anti-depressant effects, interacting with other drugs, altering their bioavailability and efficacy, were published about 20 years ago. In 2000, a pharmacokinetic interaction between SJW and cyclosporine caused acute rejection in two heart transplant patients. Since then, subsequent research has shown that SJW altered the pharmacokinetics of drugs such as digoxin, tacrolimus, indinavir, warfarin ...[more]