Ontology highlight
ABSTRACT:
SUBMITTER: Sartipy P
PROVIDER: S-EPMC165864 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Sartipy Peter P Loskutoff David J DJ
Proceedings of the National Academy of Sciences of the United States of America 20030519 12
This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive gene. It also shows that insulin induces substantial expression and secretion of MCP-1 both in vitro in insulin-resistant (IR) 3T3-L1 adipocytes and in vivo in IR obese mice (ob/ob). Thus, MCP-1 resembles other previously described genes (e.g., PAI-1 and SREBP-1c) that remain sensitive to insulin in IR states. The hyperinsulinemia that frequently accompanies obesity and insulin resistance may therefore cont ...[more]