Association between monocyte chemoattractant protein-1 and blood pressure in smokers.

ABSTRACT: Objective The expression level of monocyte chemoattractant protein-1 (MCP-1) is increased in atherosclerotic regions, inducing monocyte migration to the blood vessel wall. Although the serum MCP-1 concentration is higher in patients with than without cardiovascular disease, the precise correlations between the serum MCP-1 concentration and factors associated with smoking and atherosclerosis are unknown. Methods The serum MCP-1 concentration was measured using an enzyme-linked immunosorbent assay in 207 consecutive smokers who visited our smoking cessation clinic. Results Sex-adjusted analysis of smokers revealed that the MCP-1 concentration was positively correlated with age ( ??=?0.311), smoking duration ( ??=?0.342), systolic blood pressure ( ??=?0.225), and diastolic blood pressure ( ??=?0.137) but not with the body mass index. Multivariate regression analysis showed that smoking duration and systolic blood pressure were independent determinants of the MCP-1 concentration. Conclusions The MCP-1 concentration was positively correlated with blood pressure among smokers. Long-term smokers with high blood pressure may be more susceptible to plaque rupture at atherosclerotic lesion sites.

SUBMITTER: Komiyama M 

PROVIDER: S-EPMC5972233 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature