Ontology highlight
ABSTRACT:
SUBMITTER: Reese DK
PROVIDER: S-EPMC1676264 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Journal of virology 20060927 24
DNA helicases are essential for DNA metabolism; however, at the molecular level little is known about how they assemble or function. Therefore, as a model for a eukaryotic helicase, we are analyzing T antigen (T-ag) the helicase encoded by simian virus 40. In this study, nuclear magnetic resonance (NMR) methods were used to investigate the transit of single-stranded DNA (ssDNA) through the T-ag origin-binding domain (T-ag OBD). When the residues that interact with ssDNA are viewed in terms of th ...[more]