Proviral progeny of heterodimeric virions reveal a high crossover rate for human immunodeficiency virus type 2.
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ABSTRACT:
SUBMITTER: Mukherjee S
PROVIDER: S-EPMC1676297 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Publications
Proviral progeny of heterodimeric virions reveal a high crossover rate for human immunodeficiency virus type 2.
Mukherjee Sayandip S Lee Hui-Ling Rose HL Ron Yacov Y Dougherty Joseph P JP
Journal of virology 20061004 24
Human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS in humans, exhibits a very high rate of recombination. Bearing in mind the significant epidemiological and clinical contrast between HIV-2 and HIV-1 as well as the critical role that recombination plays in viral evolution, we examined the nature of HIV-2 recombination. Towards this end, a strategy was devised to measure the rate of crossover of HIV-2 by evaluating recombinant progeny produced exclusively by heterodimeric vi ...[more]
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