Ontology highlight
ABSTRACT:
SUBMITTER: Yang YG
PROVIDER: S-EPMC1679756 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20061102 23
NBS1 forms a complex with MRE11 and RAD50 (MRN) that is proposed to act on the upstream of two repair pathways of DNA double-strand break (DSB), homologous repair (HR) and non-homologous end joining (NHEJ). However, the function of Nbs1 in these processes has not fully been elucidated in mammals due to the lethal phenotype of cells and mice lacking Nbs1. Here, we have constructed mouse Nbs1-null embryonic fibroblasts and embryonic stem cells, through the Cre-loxP and sequential gene targeting te ...[more]