Ontology highlight
ABSTRACT:
SUBMITTER: Ramirez-Alvarado M
PROVIDER: S-EPMC16807 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Ramirez-Alvarado M M Merkel J S JS Regan L L
Proceedings of the National Academy of Sciences of the United States of America 20000801 16
There are a number of diseases in which normally soluble proteins associate into regular, insoluble amyloid fibrils. The development of in vitro model systems in which detailed structural, kinetic, and thermodynamic characterization are feasible is of critical importance to our understanding of the amyloid fibril phenomenon. The formation of amyloid fibrils by proteins that are not associated with disease has been recently described, suggesting that this may be a common property of many proteins ...[more]