Ontology highlight
ABSTRACT:
SUBMITTER: Tabach Y
PROVIDER: S-EPMC1681464 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Tabach Yuval Y Milyavsky Michael M Shats Igor I Brosh Ran R Zuk Or O Yitzhaky Assif A Mantovani Roberto R Domany Eytan E Rotter Varda V Pilpel Yitzhak Y
Molecular systems biology 20051018
Deciphering regulatory events that drive malignant transformation represents a major challenge for systems biology. Here, we analyzed genome-wide transcription profiling of an in vitro cancerous transformation process. We focused on a cluster of genes whose expression levels increased as a function of p53 and p16(INK4A) tumor suppressors inactivation. This cluster predominantly consists of cell cycle genes and constitutes a signature of a diversity of cancers. By linking expression profiles of t ...[more]