Ontology highlight
ABSTRACT:
SUBMITTER: Dorner S
PROVIDER: S-EPMC1687179 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Dorner Silke S Brunelle Julie L JL Sharma Divya D Green Rachel R
Nature structural & molecular biology 20060226 3
The GTPase elongation factor (EF)-G is responsible for promoting the translocation of the messenger RNA-transfer RNA complex on the ribosome, thus opening up the A site for the next aminoacyl-tRNA. Chemical modification and cryo-EM studies have indicated that tRNAs can bind the ribosome in an alternative 'hybrid' state after peptidyl transfer and before translocation, though the relevance of this state during translation elongation has been a subject of debate. Here, using pre-steady-state kinet ...[more]