Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC1687198 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Yang Yang Y Biedendieck Rebekka R Wang Wei W Gamer Martin M Malten Marco M Jahn Dieter D Deckwer Wolf-Dieter WD
Microbial cell factories 20061128
<h4>Background</h4>During the last years B. megaterium was continuously developed as production host for the secretion of proteins into the growth medium. Here, recombinant production and export of B. megaterium ATCC14945 penicillin G amidase (PGA) which is used in the reverse synthesis of beta-lactam antibiotics were systematically improved.<h4>Results</h4>For this purpose, the PGA leader peptide was replaced by the B. megaterium LipA counterpart. A production strain deficient in the extracellu ...[more]