Ontology highlight
ABSTRACT:
SUBMITTER: Swan MK
PROVIDER: S-EPMC1693688 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Swan Michael K MK Bastia Deepak D Davies Christopher C
Proceedings of the National Academy of Sciences of the United States of America 20061121 49
We have determined the crystal structure of a monomeric biologically active form of the pi initiator protein of plasmid R6K as a complex with a single copy of its cognate DNA-binding site (iteron) at 3.1-A resolution. The initiator belongs to the family of winged helix type of proteins. The structure reveals that the protein contacts the iteron DNA at two primary recognition helices, namely the C-terminal alpha4' and the N-terminal alpha4 helices, that recognize the 5' half and the 3' half of th ...[more]