Ontology highlight
ABSTRACT:
SUBMITTER: Komori H
PROVIDER: S-EPMC1171534 | biostudies-other | 1999 Sep
REPOSITORIES: biostudies-other
Komori H H Matsunaga F F Higuchi Y Y Ishiai M M Wada C C Miki K K
The EMBO journal 19990901 17
The initiator protein (RepE) of F factor, a plasmid involved in sexual conjugation in Escherichia coli, has dual functions during the initiation of DNA replication which are determined by whether it exists as a dimer or as a monomer. A RepE monomer functions as a replication initiator, but a RepE dimer functions as an autogenous repressor. We have solved the crystal structure of the RepE monomer bound to an iteron DNA sequence of the replication origin of plasmid F. The RepE monomer consists of ...[more]