Ontology highlight
ABSTRACT:
SUBMITTER: Oliaro J
PROVIDER: S-EPMC1693723 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Oliaro Jane J Pasam Anupama A Waterhouse Nigel J NJ Browne Kylie A KA Ludford-Menting Mandy J MJ Trapani Joseph A JA Russell Sarah M SM
Proceedings of the National Academy of Sciences of the United States of America 20061120 49
Lymphocyte function in vivo is dictated by multiple external cues, but the integration of different signals is not well understood. Here, we show that competition for the axis of polarization dictates functional outcomes. We investigated the effect of ligation of the immunoregulatory cell surface receptor, CD46, on lymphocyte polarity during antigen presentation and cytotoxic effector function. Ligation of CD46 on human T cells prevented recruitment of the microtubule organizing center, CD3, and ...[more]