Ontology highlight
ABSTRACT:
SUBMITTER: Adachi K
PROVIDER: S-EPMC3029746 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Adachi Keishi K Davis Mark M MM
Proceedings of the National Academy of Sciences of the United States of America 20110104 4
Naïve T lymphocytes display weaker and slower responses than antigen-experienced cells for reasons that are not well understood. Here we show that T-cell receptor (TCR) stimulation induces distinct ERK and p38 phosphorylation patterns in naïve and antigen-experienced human T cells, and that these contribute to the differential responses shown by these cells. Specifically, TCR ligation triggers the activation of the ERK pathway in naïve cells. This phosphorylation of ERK attenuates subsequent cal ...[more]