Ontology highlight
ABSTRACT:
SUBMITTER: Majumder S
PROVIDER: S-EPMC1694214 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Applied and environmental microbiology 20061020 12
Clostridial glucosylating cytotoxins inactivate mammalian Rho GTPases by mono-O glucosylation of a conserved threonine residue located in the switch 1 region of the target protein. Here we report that EhRho1, a RhoA-like GTPase from the protozoan parasite Entamoeba histolytica, is glucosylated by clostridial cytotoxins. Recombinant glutathione S-transferase-EhRho1 and EhRho1 from cell lysate of Entamoeba histolytica were glucosylated by Clostridium difficile toxin B and Clostridium novyi alpha-t ...[more]