Ontology highlight
ABSTRACT:
SUBMITTER: Savidge TC
PROVIDER: S-EPMC3277400 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Savidge Tor C TC Urvil Petri P Oezguen Numan N Ali Kausar K Choudhury Aproteem A Acharya Vinay V Pinchuk Irina I Torres Alfredo G AG English Robert D RD Wiktorowicz John E JE Loeffelholz Michael M Kumar Raj R Shi Lianfa L Nie Weijia W Braun Werner W Herman Bo B Hausladen Alfred A Feng Hanping H Stamler Jonathan S JS Pothoulakis Charalabos C
Nature medicine 20110821 9
The global prevalence of severe Clostridium difficile infection highlights the profound clinical significance of clostridial glucosylating toxins. Virulence is dependent on the autoactivation of a toxin cysteine protease, which is promoted by the allosteric cofactor inositol hexakisphosphate (InsP(6)). Host mechanisms that protect against such exotoxins are poorly understood. It is increasingly appreciated that the pleiotropic functions attributed to nitric oxide (NO), including host immunity, a ...[more]