Ontology highlight
ABSTRACT:
SUBMITTER: Wegierski T
PROVIDER: S-EPMC1698878 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Wegierski Tomasz T Hill Kerstin K Schaefer Michael M Walz Gerd G
The EMBO journal 20061116 24
TRPV4 is a widely expressed member of the transient receptor potential (TRP) family that facilitates Ca(2+) entry into nonexcitable cells. TRPV4 is activated by several stimuli, but it is largely unknown how the activity of this channel is terminated. Here, we show that ubiquitination represents an important mechanism to control the presence of TRPV4 at the plasma membrane. Ubiquitination of TRPV4 is dramatically increased by the HECT (homologous to E6-AP carboxyl terminus)-family ubiquitin liga ...[more]