Ontology highlight
ABSTRACT:
SUBMITTER: Opperman KJ
PROVIDER: S-EPMC5475272 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Opperman Karla J KJ Mulcahy Ben B Giles Andrew C AC Risley Monica G MG Birnbaum Rayna L RL Tulgren Erik D ED Dawson-Scully Ken K Zhen Mei M Grill Brock B
Cell reports 20170401 4
Genetic changes in the HECT ubiquitin ligase HUWE1 are associated with intellectual disability, but it remains unknown whether HUWE1 functions in post-mitotic neurons to affect circuit function. Using genetics, pharmacology, and electrophysiology, we show that EEL-1, the HUWE1 ortholog in C. elegans, preferentially regulates GABAergic presynaptic transmission. Decreasing or increasing EEL-1 function alters GABAergic transmission and the excitatory/inhibitory (E/I) balance in the worm motor circu ...[more]