Ontology highlight
ABSTRACT:
SUBMITTER: Springer TA
PROVIDER: S-EPMC1712385 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20061101 11
The recent crystal structure of complement protein component C2a reveals an interface between its VWA and serine protease domains that could not exist in the zymogen C2. The implied change in VWA domain conformation between C2 and C2a differs from that described for other VWA domains, including the I domains in integrins. Here, the remarkable diversity in both conformational regulation and ligand binding among VWA domains that function in complement, hemostasis, cell adhesion, anthrax toxin bind ...[more]