Aneuploidy and isochromosome formation in drug-resistant Candida albicans.
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ABSTRACT:
SUBMITTER: Selmecki A
PROVIDER: S-EPMC1717021 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Publications
Aneuploidy and isochromosome formation in drug-resistant Candida albicans.
Selmecki Anna A Forche Anja A Berman Judith J
Science (New York, N.Y.) 20060701 5785
Resistance to the limited number of available antifungal drugs is a serious problem in the treatment of Candida albicans. We found that aneuploidy in general and a specific segmental aneuploidy, consisting of an isochromosome composed of the two left arms of chromosome 5, were associated with azole resistance. The isochromosome forms around a single centromere flanked by an inverted repeat and was found as an independent chromosome or fused at the telomere to a full-length homolog of chromosome ...[more]
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