Ontology highlight
ABSTRACT:
SUBMITTER: Zamborlini A
PROVIDER: S-EPMC1748189 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Zamborlini Alessia A Usami Yoshiko Y Radoshitzky Sheli R SR Popova Elena E Palu Giorgio G Göttlinger Heinrich H
Proceedings of the National Academy of Sciences of the United States of America 20061204 50
The endosomal sorting complex ESCRT-III, which is formed by the structurally related CHMP proteins, is engaged by HIV-1 to promote viral budding. Here we show that progressive truncations into the C-terminal acidic domains of CHMP proteins trigger an increasingly robust anti-HIV budding activity. Together with biochemical evidence for specific intramolecular interactions between the basic and acidic halves of CHMP3 and CHMP4B, these results suggest that the acidic domains are autoinhibitory. The ...[more]