Ontology highlight
ABSTRACT:
SUBMITTER: Morita E
PROVIDER: S-EPMC3070458 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Cell host & microbe 20110301 3
Two early-acting components of the cellular ESCRT pathway, ESCRT-I and ALIX, participate directly in HIV-1 budding. The membrane fission activities of ESCRT-III subunits are also presumably required, but humans express 11 different CHMP/ESCRT-III proteins whose functional contributions are not yet clear. We therefore depleted cells of each of the different CHMP proteins and protein families and examined the effects on HIV-1 budding. Virus release was profoundly inhibited by codepletion of either ...[more]