Ontology highlight
ABSTRACT:
SUBMITTER: Horiuchi K
PROVIDER: S-EPMC1751309 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Horiuchi Keisuke K Le Gall Sylvain S Schulte Marc M Yamaguchi Takafumi T Reiss Karina K Murphy Gillian G Toyama Yoshiaki Y Hartmann Dieter D Saftig Paul P Blobel Carl P CP
Molecular biology of the cell 20061101 1
Signaling via the epidermal growth factor receptor (EGFR), which has critical roles in development and diseases such as cancer, is regulated by proteolytic shedding of its membrane-tethered ligands. Sheddases for EGFR-ligands are therefore key signaling switches in the EGFR pathway. Here, we determined which ADAMs (a disintegrin and metalloprotease) can shed various EGFR-ligands, and we analyzed the regulation of EGFR-ligand shedding by two commonly used stimuli, phorbol esters and calcium influ ...[more]