Impaired phagocytic mechanism in annexin 1 null macrophages.
Ontology highlight
ABSTRACT:
SUBMITTER: Yona S
PROVIDER: S-EPMC1751776 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Publications
Impaired phagocytic mechanism in annexin 1 null macrophages.
Yona Simon S Heinsbroek Sigrid E M SE Peiser Leanne L Gordon Siamon S Perretti Mauro M Flower Roderick J RJ
British journal of pharmacology 20060424 4
The role of the anti-inflammatory protein annexin-A1 (Anx-A1) in the phagocytic process has been investigated using a murine bone marrow culture-derived macrophage model from Anx-A1(+/+) and Anx-A1(-/-) mice. Macrophages prepared from Anx-A1(-/-) mice exhibited a reduced ingestion of zymosan, Neisseria meningitidis or sheep red blood cells, when compared to Anx-A1(+/+) cells and in the case of zymosan this effect was also mirrored by a reduced clearance in vivo when particles were injected into ...[more]
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