Ontology highlight
ABSTRACT:
SUBMITTER: Rangel R
PROVIDER: S-EPMC1815469 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Rangel Roberto R Sun Yan Y Guzman-Rojas Liliana L Ozawa Michael G MG Sun Jessica J Giordano Ricardo J RJ Van Pelt Carolyn S CS Tinkey Peggy T PT Behringer Richard R RR Sidman Richard L RL Arap Wadih W Pasqualini Renata R
Proceedings of the National Academy of Sciences of the United States of America 20070307 11
Aminopeptidase N (APN, CD13; EC 3.4.11.2) is a transmembrane metalloprotease with several functions, depending on the cell type and tissue environment. In tumor vasculature, APN is overexpressed in the endothelium and promotes angiogenesis. However, there have been no reports of in vivo inactivation of the APN gene to validate these findings. Here we evaluated, by targeted disruption of the APN gene, whether APN participates in blood vessel formation and function under normal conditions. Surpris ...[more]