Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation.
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ABSTRACT:
SUBMITTER: Rachman H
PROVIDER: S-EPMC1762319 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Publications
Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation.
Rachman Helmy H Kim Nayoung N Ulrichs Timo T Baumann Sven S Pradl Lydia L Nasser Eddine Ali A Bild Matthias M Rother Marion M Kuban Ralf-Jürgen RJ Lee Jong Seok JS Hurwitz Robert R Brinkmann Volker V Kosmiadi George A GA Kaufmann Stefan H E SH
PloS one 20061220
Apoptosis and activation of macrophages play an important role in the host response to mycobacterial infection involving TNF-alpha as a critical autocrine mediator. The underlying mechanisms are still ill-defined. Here, we demonstrate elevated levels of methylglyoxal (MG), a small and reactive molecule that is usually a physiological product of various metabolic pathways, and advanced glycation end products (AGE) during mycobacterial infection of macrophages, leading to apoptosis and activation ...[more]
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