Ontology highlight
ABSTRACT:
SUBMITTER: Blackman SM
PROVIDER: S-EPMC1764617 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Blackman Scott M SM Deering-Brose Rebecca R McWilliams Rita R Naughton Kathleen K Coleman Barbara B Lai Teresa T Algire Marilyn M Beck Suzanne S Hoover-Fong Julie J Hamosh Ada A Fallin M Daniele MD West Kristen K Arking Dan E DE Chakravarti Aravinda A Cutler David J DJ Cutting Garry R GR
Gastroenterology 20060724 4
<h4>Background & aims</h4>Neonatal intestinal obstruction (meconium ileus [MI]) occurs in 15% of patients with cystic fibrosis (CF). Our aim was to determine the relative contribution of genetic and nongenetic modifiers to the development of this major complication of CF.<h4>Methods</h4>A total of 65 monozygous twin pairs, 23 dizygous twin/triplet sets, and 349 sets of siblings with CF were analyzed for MI status, significant covariates, and genome-wide linkage.<h4>Results</h4>Specific mutations ...[more]