Melanoma inhibitor of apoptosis protein is expressed differentially in melanoma and melanocytic naevus, but similarly in primary and metastatic melanomas.
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ABSTRACT:
SUBMITTER: Gong J
PROVIDER: S-EPMC1770742 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Publications
Melanoma inhibitor of apoptosis protein is expressed differentially in melanoma and melanocytic naevus, but similarly in primary and metastatic melanomas.
Gong J J Chen N N Zhou Q Q Yang B B Wang Y Y Wang X X
Journal of clinical pathology 20051001 10
<h4>Background</h4>Malignant melanoma is highly resistant to current treatments. The inhibitor of apoptosis protein (IAP) family member, melanoma IAP (ML-IAP), is overexpressed in some melanoma cell lines, rendering them resistant to apoptotic signals. Targeting ML-IAP is a promising approach to treating melanoma. However, the status of ML-IAP expression in human melanoma tissues and the difference in expression between melanoma and melanocytic naevus are not known.<h4>Aims</h4>To investigate th ...[more]
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