Ontology highlight
ABSTRACT:
SUBMITTER: Bauer H
PROVIDER: S-EPMC1770897 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Bauer Hermann H Véron Nathalie N Willert Jürgen J Herrmann Bernhard G BG
Genes & development 20070101 2
Transmission ratio distortion (TRD), the preferential inheritance of the t haplotype from t/+ males, is caused by the cooperative effect of four t-complex distorters (Tcd1-4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region. The t allele of Fgd2 is overexpressed in testis compared with wild type. A loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio ...[more]