Ontology highlight
ABSTRACT:
SUBMITTER: Bean BD
PROVIDER: S-EPMC4357511 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Bean Bjorn D M BD Davey Michael M Snider Jamie J Jessulat Matthew M Deineko Viktor V Tinney Matthew M Stagljar Igor I Babu Mohan M Conibear Elizabeth E
Molecular biology of the cell 20150121 6
The retromer complex facilitates the sorting of integral membrane proteins from the endosome to the late Golgi. In mammalian cells, the efficient recruitment of retromer to endosomes requires the lipid phosphatidylinositol 3-phosphate (PI3P) as well as Rab5 and Rab7 GTPases. However, in yeast, the role of Rabs in recruiting retromer to endosomes is less clear. We identified novel physical interactions between retromer and the Saccharomyces cerevisiae VPS9-domain Rab5-family guanine nucleotide ex ...[more]