Ontology highlight
ABSTRACT:
SUBMITTER: Cavrois M
PROVIDER: S-EPMC1779297 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Cavrois Marielle M Neidleman Jason J Kreisberg Jason F JF Greene Warner C WC
PLoS pathogens 20070101 1
In the prevailing model of HIV-1 trans-infection, dendritic cells (DCs) capture and internalize intact virions and transfer these virions to interacting T cells at the virological synapse. Here, we show that HIV-1 virions transmitted in trans from in vitro derived DCs to T cells principally originate from the surface of DCs. Selective neutralization of surface-bound virions abrogated trans-infection by monocyte-derived DCs and CD34-derived Langerhans cells. Under conditions mimicking antigen rec ...[more]