Ontology highlight
ABSTRACT:
SUBMITTER: Gaspar M
PROVIDER: S-EPMC3213091 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Gaspar Miguel M May Janet S JS Sukla Soumi S Frederico Bruno B Gill Michael B MB Smith Christopher M CM Belz Gabrielle T GT Stevenson Philip G PG
PLoS pathogens 20111110 11
Dendritic cells (DCs) play a central role in initiating immune responses. Some persistent viruses infect DCs and can disrupt their functions in vitro. However, these viruses remain strongly immunogenic in vivo. Thus what role DC infection plays in the pathogenesis of persistent infections is unclear. Here we show that a persistent, B cell-tropic gamma-herpesvirus, Murid Herpesvirus-4 (MuHV-4), infects DCs early after host entry, before it establishes a substantial infection of B cells. DC-specif ...[more]