Ontology highlight
ABSTRACT:
SUBMITTER: Efroni S
PROVIDER: S-EPMC1782042 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Efroni Sol S Harel David D Cohen Irun R IR
PLoS computational biology 20061211 1
Experiments have generated a plethora of data about the genes, molecules, and cells involved in thymocyte development. Here, we use a computer-driven simulation that uses data about thymocyte development to generate an integrated dynamic representation-a novel technology we have termed reactive animation (RA). RA reveals emergent properties in complex dynamic biological systems. We apply RA to thymocyte development by reproducing and extending the effects of known gene knockouts: CXCR4 and CCR9. ...[more]