Ontology highlight
ABSTRACT:
SUBMITTER: Poteryaev D
PROVIDER: S-EPMC1783445 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Poteryaev Dmitry D Fares Hanna H Bowerman Bruce B Spang Anne A
The EMBO journal 20070104 2
The small rab-GTPase RAB-7 acts in endosome and endosome to lysosome traffic. We identified SAND-1 as a protein required for RAB-7 function based on similarities between SAND-1 and RAB-7 RNAi phenotypes. Although the initial uptake of yolk protein in oocytes, or of soluble secreted (ss) GFP in coelomocytes, appeared normal, further transport along the endocytic traffic route was delayed in the absence of SAND-1 function, and yolk proteins failed to reach yolk granules efficiently. Moreover, in c ...[more]