Ontology highlight
ABSTRACT:
SUBMITTER: Sasidharan N
PROVIDER: S-EPMC3503202 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Sasidharan Nikhil N Sumakovic Marija M Hannemann Mandy M Hegermann Jan J Liewald Jana F JF Olendrowitz Christian C Koenig Sabine S Grant Barth D BD Rizzoli Silvio O SO Gottschalk Alexander A Eimer Stefan S
Proceedings of the National Academy of Sciences of the United States of America 20121025 46
Neurons secrete neuropeptides from dense core vesicles (DCVs) to modulate neuronal activity. Little is known about how neurons manage to differentially regulate the release of synaptic vesicles (SVs) and DCVs. To analyze this, we screened all Caenorhabditis elegans Rab GTPases and Tre2/Bub2/Cdc16 (TBC) domain containing GTPase-activating proteins (GAPs) for defects in DCV release from C. elegans motoneurons. rab-5 and rab-10 mutants show severe defects in DCV secretion, whereas SV exocytosis is ...[more]