Ontology highlight
ABSTRACT:
SUBMITTER: Karakas E
PROVIDER: S-EPMC1783470 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
The EMBO journal 20070101 2
Removal and repair of DNA damage by the nucleotide excision repair pathway requires two sequential incision reactions, which are achieved by the endonuclease UvrC in eubacteria. Here, we describe the crystal structure of the C-terminal half of UvrC, which contains the catalytic domain responsible for 5' incision and a helix-hairpin-helix-domain that is implicated in DNA binding. Surprisingly, the 5' catalytic domain shares structural homology with RNase H despite the lack of sequence homology an ...[more]