Ontology highlight
ABSTRACT:
SUBMITTER: Legg JA
PROVIDER: S-EPMC1783773 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Legg John A JA Bompard Guillaume G Dawson John J Morris Hannah L HL Andrew Natalie N Cooper Lisa L Johnston Simon A SA Tramountanis Giorgos G Machesky Laura M LM
Molecular biology of the cell 20061220 2
The Wiskott-Aldrich syndrome protein (WASP) family activates the Arp2/3 complex leading to the formation of new actin filaments. Here, we study the involvement of Scar1, Scar2, N-WASP, and Arp2/3 complex in dorsal ruffle formation in mouse embryonic fibroblasts (MEFs). Using platelet-derived growth factor to stimulate circular dorsal ruffle assembly in primary E13 and immortalized E9 Scar1(+/+) and Scar1 null MEFs, we establish that Scar1 loss does not impair the formation of dorsal ruffles. Red ...[more]