Ontology highlight
ABSTRACT:
SUBMITTER: Cortesio CL
PROVIDER: S-EPMC2801713 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Cortesio Christa L CL Perrin Benjamin J BJ Bennin David A DA Huttenlocher Anna A
Molecular biology of the cell 20091112 1
Growth factor stimulation induces the formation of dynamic actin structures known as dorsal ruffles. Mammalian actin-binding protein-1 (mAbp1) is an actin-binding protein that has been implicated in regulating clathrin-mediated endocytosis; however, a role for mAbp1 in regulating the dynamics of growth factor-induced actin-based structures has not been defined. Here we show that mAbp1 localizes to dorsal ruffles and is necessary for platelet-derived growth factor (PDGF)-mediated dorsal ruffle fo ...[more]