Ontology highlight
ABSTRACT:
SUBMITTER: Kopp K
PROVIDER: S-EPMC1783775 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20061115 2
Pre-rRNA synthesis and processing are key steps in ribosome biogenesis. Although recent evidence in yeast suggests that these two processes are coupled, the nature of their association is unclear. In this report, we analyze the coordination between rDNA transcription and pre-rRNA processing in mammalian cells. We found that pol I transcription factor UBF interacts with pre-rRNA processing factors as analyzed by immunoprecipitations, and the association depends on active rRNA synthesis. In additi ...[more]