Ontology highlight
ABSTRACT:
SUBMITTER: Comini MA
PROVIDER: S-EPMC1783994 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Comini Marcelo A MA Krauth-Siegel R Luise RL Flohé Leopold L
The Biochemical journal 20070201 1
In trypanosomes, the thioredoxin-type protein TXN (tryparedoxin) is a multi-purpose oxidoreductase that is involved in the detoxification of hydroperoxides, the synthesis of DNA precursors and the replication of the kinetoplastid DNA. African trypanosomes possess two isoforms that are localized in the cytosol and in the mitochondrion of the parasites respectively. Here we report on the biological significance of the cTXN (cytosolic TXN) of Trypanosoma brucei for hydroperoxide detoxification. Dep ...[more]