Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.
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SUBMITTER: Meyer-Lindenberg A
PROVIDER: S-EPMC1784004 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
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Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.
Meyer-Lindenberg Andreas A Straub Richard E RE Lipska Barbara K BK Verchinski Beth A BA Goldberg Terry T Callicott Joseph H JH Egan Michael F MF Huffaker Stephen S SS Mattay Venkata S VS Kolachana Bhaskar B Kleinman Joel E JE Weinberger Daniel R DR
The Journal of clinical investigation 20070208 3
Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32), encoded by PPP1R1B, is a pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and drugs of abuse, and affecting striatal function and plasticity. Despite extensive preclinical work, there are almost no data on DARPP-32 function in humans. Here, we identify, through resequencing in 298 chromosomes, a frequent PPP1R1B haplotype predicting mRNA expre ...[more]
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