Influence of DARPP-32 genetic variation on BOLD activation to happy faces.
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ABSTRACT:
SUBMITTER: Persson N
PROVIDER: S-EPMC5647797 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Influence of DARPP-32 genetic variation on BOLD activation to happy faces.
Persson Ninni N Lavebratt Catarina C Ebner Natalie C NC Fischer Håkan H
Social cognitive and affective neuroscience 20171001 10
Dopaminergic pathways play a crucial role in reward processing, and advanced age can modulate its efficiency. DARPP-32 controls dopaminergic function and is a chemical nexus of reward processing. In 61 younger (20-30 years) and older adults (54% ♀) (65-74 years), we examined how blood-oxygen-level dependent (BOLD) activation to emotional faces, vary over genotypes at three single nucleotide polymorphism (SNPs), coding for DARPP-32 (rs879606; rs907094; 3764352). We also assessed age-magnification ...[more]
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