Ontology highlight
ABSTRACT:
SUBMITTER: Zhan F
PROVIDER: S-EPMC1794073 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Zhan Fenghuang F Barlogie Bart B Arzoumanian Varant V Huang Yongsheng Y Williams David R DR Hollmig Klaus K Pineda-Roman Mauricio M Tricot Guido G van Rhee Frits F Zangari Maurizio M Dhodapkar Madhav M Shaughnessy John D JD
Blood 20061005 4
Monoclonal gammopathy of undetermined significance (MGUS) can progress to multiple myeloma (MM). Although these diseases share many of the same genetic features, it is still unclear whether global gene-expression profiling might identify prior genomic signatures that distinguish them. Through significance analysis of microarrays, 52 genes involved in important pathways related to cancer were differentially expressed in the plasma cells of healthy subjects (normal plasma-cell [NPC]; n=22) and pat ...[more]