Dataset Information

Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.

ABSTRACT:

Background

Glyphosate is the most widely used herbicide in the USA and worldwide. There has been considerable debate about its carcinogenicity. Epidemiological studies suggest that multiple myeloma (MM) and non-Hodgkin lymphoma (NHL) have a positive and statistically significant association with glyphosate exposure. As a B cell genome mutator, activation-induced cytidine deaminase (AID) is a key pathogenic player in both MM and B cell NHL.

Methods

Vk*MYC is a mouse line with sporadic MYC activation in germinal center B cells and considered as the best available MM animal model. We treated Vk*MYC mice and wild-type mice with drinking water containing 1000?mg/L of glyphosate and examined animals after 72?weeks.

Results

Vk*MYC mice under glyphosate exposure developed progressive hematological abnormalities and plasma cell neoplasms such as splenomegaly, anemia, and high serum IgG. Moreover, glyphosate caused multiple organ dysfunction, including lytic bone lesions and renal damage in Vk*MYC mice. Glyphosate-treated wild-type mice developed benign monoclonal gammopathy with increased serum IgG, anemia, and plasma cell presence in the spleen and bone marrow. Finally, glyphosate upregulated AID in the spleen and bone marrow of both wild-type and Vk*MYC mice.

Conclusions

These data support glyphosate as an environmental risk factor for MM and potentially NHL and implicate a mechanism underlying the B cell-specificity of glyphosate-induced carcinogenesis observed epidemiologically.

SUBMITTER: Wang L

PROVIDER: S-EPMC6612199 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.

Wang Lei L Deng Qipan Q Hu Hui H Liu Ming M Gong Zhaojian Z Zhang Shanshan S Xu-Monette Zijun Y ZY Lu Zhongxin Z Young Ken H KH Ma Xiaodong X Li Yong Y

Journal of hematology & oncology 20190705 1

<h4>Background</h4>Glyphosate is the most widely used herbicide in the USA and worldwide. There has been considerable debate about its carcinogenicity. Epidemiological studies suggest that multiple myeloma (MM) and non-Hodgkin lymphoma (NHL) have a positive and statistically significant association with glyphosate exposure. As a B cell genome mutator, activation-induced cytidine deaminase (AID) is a key pathogenic player in both MM and B cell NHL.<h4>Methods</h4>Vk*MYC is a mouse line with spora ...[more]

PMID: 31277689

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Dataset Information

Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.

Background

Methods

Results

Conclusions

Publications

Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.

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