Ontology highlight
ABSTRACT:
SUBMITTER: Kepp O
PROVIDER: S-EPMC1794390 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20070118 3
Mitochondrial outer membrane permeabilization (MOMP) and release of mitochondrial intermembrane proteins like cytochrome c are critical steps in the control of apoptosis. Previous work has shown that MOMP depends on the functionally redundant multidomain proapoptotic proteins, Bak and Bax. Here we demonstrate that Bak and Bax are functionally non-redundant during Neisseria gonorrhoeae (Ngo)- and cisplatin-induced apoptosis. While the activation of Bak is caspase independent Bax activation needs ...[more]