Ontology highlight
ABSTRACT:
SUBMITTER: Lum AM
PROVIDER: S-EPMC1794537 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Lum Amy M AM Wang Bruce B BB Li Lauri L Channa Namitha N Bartha Gabor G Wabl Matthias M
Retrovirology 20070125
Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a an ...[more]