Ontology highlight
ABSTRACT:
SUBMITTER: Wang CL
PROVIDER: S-EPMC1693722 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Wang Clifford L CL Wang Bruce B BB Bartha Gábor G Li Lauri L Channa Namitha N Klinger Mark M Killeen Nigel N Wabl Matthias M
Proceedings of the National Academy of Sciences of the United States of America 20061122 49
Retroviruses can cause tumors when they integrate near a protooncogene or tumor suppressor gene of the host. We infected >2,500 mice with the SL3-3 murine leukemia virus; in 22 resulting tumors, we found provirus integrations nearby or within the gene that contains the mir-17-92 microRNA (miRNA) cistron. Using quantitative real-time PCR, we showed that expression of miRNA was increased in these tumors, indicating that retroviral infection can induce expression of oncogenic miRNAs. Our results de ...[more]