Ontology highlight
ABSTRACT:
SUBMITTER: Knauer SK
PROVIDER: S-EPMC1794705 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Knauer Shirley K SK Bier Carolin C Habtemichael Negusse N Stauber Roland H RH
EMBO reports 20061110 12
The chromosomal passenger complex (CPC) of Aurora-B, Borealin, INCENP (inner centromere protein) and Survivin coordinates essential chromosomal and cytoskeletal events during mitosis. Here, we show that the nuclear export receptor Crm1 is crucially involved in tethering the CPC to the centromere by interacting with a leucine-rich nuclear export signal (NES), evolutionarily conserved in all mammalian Survivin proteins. We show that inhibition of the Survivin-Crm1 interaction by treatment with lep ...[more]